{"id":702,"date":"2022-11-15T14:05:38","date_gmt":"2022-11-15T14:05:38","guid":{"rendered":"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/?p=702"},"modified":"2025-11-18T20:09:45","modified_gmt":"2025-11-18T20:09:45","slug":"mrt-maldi-tof","status":"publish","type":"post","link":"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/mrt-maldi-tof\/","title":{"rendered":"Mass Spectral Imaging"},"content":{"rendered":"<p>[vc_row][vc_column][vc_column_text]MALDI-TOF-MS (Matrix-Assisted Laser Desorption\/Ionization Time-of-Flight Mass Spectrometry) is an analytical technique used to determine the molecular weight and composition of biomolecules like proteins, peptides, and polymers. In MALDI-TOF-MS, samples are mixed with a matrix material and irradiated with a laser, which causes the matrix to absorb the laser energy and facilitate the ionisation of the sample. The resulting ions are then accelerated through a time-of-flight analyser, which measures their mass-to-charge ratio based on the time it takes for the ions to reach the detector. This technique is valued for its sensitivity, speed, and ability to analyse complex mixtures with high accuracy.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_basic_grid post_type=&#8221;post&#8221; max_items=&#8221;10&#8243; grid_id=&#8221;vc_gid:1723198365669-37d76eca-2ec1-4&#8243; taxonomies=&#8221;57&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text]MALDI-TOF-MS (Matrix-Assisted Laser Desorption\/Ionization Time-of-Flight Mass Spectrometry) is an analytical technique used to determine the molecular weight and composition of biomolecules like proteins, peptides, and polymers. In MALDI-TOF-MS, samples are&#8230;<a class=\"read-more\" href=\"&#104;&#116;&#116;&#112;&#115;&#58;&#47;&#47;&#114;&#101;&#115;&#101;&#97;&#114;&#99;&#104;&#46;&#114;&#101;&#97;&#100;&#105;&#110;&#103;&#46;&#97;&#99;&#46;&#117;&#107;&#47;&#99;&#104;&#101;&#109;&#105;&#99;&#97;&#108;&#45;&#97;&#110;&#97;&#108;&#121;&#115;&#105;&#115;&#45;&#102;&#97;&#99;&#105;&#108;&#105;&#116;&#121;&#47;&#109;&#114;&#116;&#45;&#109;&#97;&#108;&#100;&#105;&#45;&#116;&#111;&#102;&#47;\">Read More ><\/a><\/p>\n","protected":false},"author":585,"featured_media":1854,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"__cvm_playback_settings":[],"__cvm_video_id":"","footnotes":""},"categories":[87,57],"tags":[],"coauthors":[11],"class_list":["post-702","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-application","category-waters-mrt"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mass Spectral Imaging - Chemical Analysis Facility (CAF)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/mrt-maldi-tof\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mass Spectral Imaging - Chemical Analysis Facility (CAF)\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text]MALDI-TOF-MS (Matrix-Assisted Laser Desorption\/Ionization Time-of-Flight Mass Spectrometry) is an analytical technique used to determine the molecular weight and composition of biomolecules like proteins, peptides, and polymers. In MALDI-TOF-MS, samples are...Read More &gt;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/mrt-maldi-tof\/\" \/>\n<meta property=\"og:site_name\" content=\"Chemical Analysis Facility (CAF)\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-15T14:05:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-18T20:09:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/wp-content\/uploads\/sites\/252\/2025\/11\/CAF-Lab-JJT-031.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1281\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Gunter Kuhnle\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UniRdg_CAF\" \/>\n<meta name=\"twitter:site\" content=\"@UniRdg_CAF\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Gunter Kuhnle\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/mrt-maldi-tof\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/mrt-maldi-tof\/\"},\"author\":{\"name\":\"Gunter Kuhnle\",\"@id\":\"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/#\/schema\/person\/cdd8b9e621a776095ed7786e01e29531\"},\"headline\":\"Mass Spectral Imaging\",\"datePublished\":\"2022-11-15T14:05:38+00:00\",\"dateModified\":\"2025-11-18T20:09:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/mrt-maldi-tof\/\"},\"wordCount\":145,\"publisher\":{\"@id\":\"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/#organization\"},\"articleSection\":[\"Application\",\"Waters MRT\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/mrt-maldi-tof\/\",\"url\":\"https:\/\/research.reading.ac.uk\/chemical-analysis-facility\/mrt-maldi-tof\/\",\"name\":\"Mass Spectral Imaging - 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