{"id":6817,"date":"1024-05-03T14:08:14","date_gmt":"1024-05-03T14:09:29","guid":{"rendered":"https:\/\/research.reading.ac.uk\/cinn\/?p=6817"},"modified":"2024-06-03T17:01:58","modified_gmt":"2024-06-03T16:01:58","slug":"aut-b6","status":"publish","type":"post","link":"https:\/\/research.reading.ac.uk\/cinn\/aut-b6\/","title":{"rendered":"The effects of Vitamin B6 on sensory reactivity and anxiety in autistic adults"},"content":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]<\/p>\n<div class=\"ewa-rteLine\">Sensory hypersensitivity is reported in ~95% of autistic individuals and anxiety is reported in ~30% of autistic individuals. Theories have proposed that this sensory hypersensitivity and anxiety may be driven by an imbalance between neurotransmitters called GABA and glutamate. Here we want to see if by giving high doses of vitamin B6, a water-soluble vitamin, we can have an impact on sensory reactivity, anxiety and\/or depression. In previous research, we have demonstrated that vitamin B6 affects sensory hypersensitivity and anxiety in non-autistic people, and we would like to see if this can also be shown in autistic individuals. The study involves a series of questionnaires, visual perception tasks (e.g. you have to look at a computer screen and tell us what you see), and a blood test before and after a 30-day intervention of vitamin B6 or a placebo. You will be asked to complete questionnaires asking about your mood, diet, and lifestyle before then being asked to complete a series of visual perception tasks. These visual perception tasks will involve reporting which circle presented to you appears bigger and the direction of lines inside of circles. Finally, we will collect a blood sample from you using a novel technique that has been shown to be virtually painless in autistic and non-autistic adults (called TAP-II devices). You will then be asked to return and complete these tasks after 30 days of taking tablets. For more information, please read the information sheet included here.<\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_btn title=&#8221;Participant Information Sheet&#8221; color=&#8221;primary&#8221; link=&#8221;url:https%3A%2F%2Fresearch.reading.ac.uk%2Fcinn%2Fwp-content%2Fuploads%2Fsites%2F111%2F2024%2F05%2FInformation-sheet.pdf&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]<\/p>\n<div class=\"ewa-rteLine\">You <span style=\"text-decoration: underline\">can<\/span> take part in this study if:<\/div>\n<ul>\n<li class=\"ewa-rteLine\">You have received a diagnosis of autism<\/li>\n<li class=\"ewa-rteLine\">You are 18-60 years old<\/li>\n<\/ul>\n<div><\/div>\n<div class=\"ewa-rteLine\">You <span style=\"text-decoration: underline\">cannot<\/span> take part in this study if:<\/div>\n<ul>\n<li class=\"ewa-rteLine\">You are taking, or have recently taken, any multivitamin or supplement that contains more than 2 mg of Vitamin B6<\/li>\n<li class=\"ewa-rteLine\">You are taking drugs that are known GABA agonists, such as Arbaclofen<\/li>\n<li class=\"ewa-rteLine\">You have a history of peripheral neuropathy<\/li>\n<li class=\"ewa-rteLine\">You have taken or are currently taking the antibiotic cycloserine<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<div class=\"ewa-rteLine\"><\/div>\n<div>For more information, please contact Alex Cameron (<a href=\"mailto:a.cameron@pgr.reading.ac.uk\">a.cameron@pgr.reading.ac.uk<\/a>)<\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text] Sensory hypersensitivity is reported in ~95% of autistic individuals and anxiety is reported in ~30% of autistic individuals. Theories have proposed that this sensory hypersensitivity&#8230;<a class=\"read-more\" href=\"&#104;&#116;&#116;&#112;&#115;&#58;&#47;&#47;&#114;&#101;&#115;&#101;&#97;&#114;&#99;&#104;&#46;&#114;&#101;&#97;&#100;&#105;&#110;&#103;&#46;&#97;&#99;&#46;&#117;&#107;&#47;&#99;&#105;&#110;&#110;&#47;&#97;&#117;&#116;&#45;&#98;&#54;&#47;\">Read More ><\/a><\/p>\n","protected":false},"author":471,"featured_media":1940,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"__cvm_playback_settings":[],"__cvm_video_id":"","footnotes":""},"categories":[306,305],"tags":[],"class_list":["post-6817","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ongoing","category-research-study"],"acf":[],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The effects of Vitamin B6 on sensory reactivity and anxiety in autistic adults - Centre for Integrative Neuroscience and Neurodynamics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.reading.ac.uk\/cinn\/aut-b6\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The effects of Vitamin B6 on sensory reactivity and anxiety in autistic adults - Centre for Integrative Neuroscience and Neurodynamics\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;1\/4&#8243;][vc_single_image source=&#8221;featured_image&#8221; img_size=&#8221;full&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text] Sensory hypersensitivity is reported in ~95% of autistic individuals and anxiety is reported in ~30% of autistic individuals. Theories have proposed that this sensory hypersensitivity...Read More &gt;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/research.reading.ac.uk\/cinn\/aut-b6\/\" \/>\n<meta property=\"og:site_name\" content=\"Centre for Integrative Neuroscience and Neurodynamics\" \/>\n<meta property=\"article:published_time\" content=\"1024-05-03T14:09:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-06-03T16:01:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/research.reading.ac.uk\/cinn\/wp-content\/uploads\/sites\/111\/CINN\/brain-colours.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"750\" \/>\n\t<meta property=\"og:image:height\" content=\"450\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Anastasia Christakou\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UniRdg_CINN\" \/>\n<meta name=\"twitter:site\" content=\"@UniRdg_CINN\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Anastasia Christakou\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/research.reading.ac.uk\/cinn\/aut-b6\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/research.reading.ac.uk\/cinn\/aut-b6\/\"},\"author\":{\"name\":\"Anastasia Christakou\",\"@id\":\"https:\/\/research.reading.ac.uk\/cinn\/#\/schema\/person\/22f15884f08b8fc93fb50e4cd1a519ec\"},\"headline\":\"The effects of Vitamin B6 on sensory reactivity and anxiety in autistic adults\",\"datePublished\":\"1024-05-03T14:09:29+00:00\",\"dateModified\":\"2024-06-03T16:01:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/research.reading.ac.uk\/cinn\/aut-b6\/\"},\"wordCount\":433,\"publisher\":{\"@id\":\"https:\/\/research.reading.ac.uk\/cinn\/#organization\"},\"articleSection\":[\"Ongoing\",\"Research Study\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/research.reading.ac.uk\/cinn\/aut-b6\/\",\"url\":\"https:\/\/research.reading.ac.uk\/cinn\/aut-b6\/\",\"name\":\"The effects of Vitamin B6 on sensory reactivity and anxiety in autistic adults - 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