{"id":2068,"date":"2024-06-05T11:56:55","date_gmt":"2024-06-05T10:56:55","guid":{"rendered":"https:\/\/research.reading.ac.uk\/engagement-and-impact\/?p=2068"},"modified":"2024-06-17T10:06:06","modified_gmt":"2024-06-17T09:06:06","slug":"research-output-prize-2024-gemma-little","status":"publish","type":"post","link":"https:\/\/research.reading.ac.uk\/engagement-and-impact\/research-output-prize-2024-gemma-little\/","title":{"rendered":"Research Output Prize 2024 &#8211; Gemma Little"},"content":{"rendered":"<p>[vc_row][vc_column][vc_column_text]<\/p>\n<h2><strong>Immobility-associated thrombo-protection is conserved across mammalian species from bear to human<\/strong><\/h2>\n<p>Deep vein thrombosis (DVT) is a life-threatening condition that occurs when a blood\u00a0clot occurs within a vein. DVT is commonly triggered by immobilisation. Curiously, long-term immobility does not trigger DVT and the reason for this was not previously understood. In this study, it was discovered that long-term immobilisation changes the levels of a protein in blood platelets, and this prevents DVT. Gemma helped determine the molecular mechanisms that explain this process by producing conditional transgenic mice that lacked the protein and studying their platelets and megakaryocytes.<\/p>\n<p>Gemma Little is a Research Assistant in Biomedical Sciences at the University of Reading and winner of the University\u2019s 2024 Research Output Prize (Agriculture, Food &amp; Health theme) for her paper as co-author published in\u00a0Science: \u2018<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abo5044\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Immobility-associated thrombo-protection is conserved across mammalian species from bear to human\u2019<\/em><\/a>.<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] Immobility-associated thrombo-protection is conserved across mammalian species from bear to human Deep vein thrombosis (DVT) is a life-threatening condition that occurs when a blood\u00a0clot occurs within a vein. DVT&#8230;<a class=\"read-more\" href=\"&#104;&#116;&#116;&#112;&#115;&#58;&#47;&#47;&#114;&#101;&#115;&#101;&#97;&#114;&#99;&#104;&#46;&#114;&#101;&#97;&#100;&#105;&#110;&#103;&#46;&#97;&#99;&#46;&#117;&#107;&#47;&#101;&#110;&#103;&#97;&#103;&#101;&#109;&#101;&#110;&#116;&#45;&#97;&#110;&#100;&#45;&#105;&#109;&#112;&#97;&#99;&#116;&#47;&#114;&#101;&#115;&#101;&#97;&#114;&#99;&#104;&#45;&#111;&#117;&#116;&#112;&#117;&#116;&#45;&#112;&#114;&#105;&#122;&#101;&#45;&#50;&#48;&#50;&#52;&#45;&#103;&#101;&#109;&#109;&#97;&#45;&#108;&#105;&#116;&#116;&#108;&#101;&#47;\">Read More ><\/a><\/p>\n","protected":false},"author":469,"featured_media":2102,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"__cvm_playback_settings":[],"__cvm_video_id":"","footnotes":""},"categories":[243],"tags":[],"coauthors":[90],"class_list":["post-2068","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ecr-output-prize-2024"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research Output Prize 2024 - Gemma Little - Engagement and Impact<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.reading.ac.uk\/engagement-and-impact\/research-output-prize-2024-gemma-little\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Output Prize 2024 - Gemma Little - Engagement and Impact\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text] Immobility-associated thrombo-protection is conserved across mammalian species from bear to human Deep vein thrombosis (DVT) is a life-threatening condition that occurs when a blood\u00a0clot occurs within a vein. 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