On this project
On Liquid-atmospheric-pressure Matrix-assisted laser desorption/ionization (LAP-MALDI-MS)
Challen, B., Cramer, R. (2022) Advances in ionisation techniques for mass spectrometry-based omics research. Proteomics , doi: 10.1002/pmic.202100394. In press
Piras, C. , Greco, V. , Gugliandolo, E. , Soggiu, A. , Tilocca, B. , Bonizzi, L. , Zecconi, A. , Cramer, R. , Britti, D. , Urbani, A. , Roncada, P. (2020) Raw cow milk bacterial consortium as bioindicator of circulating anti-microbial resistance (AMR). Animal Feed Science and Technology , 10 (12). ISSN: 0377-8401 | doi: https://dx.doi.org/10.3390/ani10122378
Hale, O. , Ryumin, P. , Brown, J. , Morris, M. , Cramer, R. (2020) Production and analysis of multiply charged negative ions by liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Rapid Communications in Mass Spectrometry , 35 (S1). ISSN: 1097-0231 | doi: https://dx.doi.org/10.1002/rcm.8246
Lellman, S. and Cramer, R. (2019) Bacterial identification by lipid profiling using liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Clinical Chemistry and Laboratory Medicine , 58 (6). pp. 930-938. ISSN: 1437-4331 | doi: https://dx.doi.org/10.1515/cclm-2019-0908
Hale, O. and Cramer, R. (2019) Atmospheric pressure ultraviolet laser desorption and ionization from liquid samples for native mass spectrometry. Analytical Chemistry , 91 (22). pp. 14192-14197. ISSN: 0003-2700 | doi: https://dx.doi.org/10.1021/acs.analchem.9b03875
Hale, O. , Morris, M. , Jones, B. , Reynolds, C. , Cramer, R. (2019) Liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry adds enhanced functionalities to MALDI MS profiling for disease diagnostics. ACS Omega , 4 (7). pp. 12759-12765. ISSN: 2470-1343 | doi: https://dx.doi.org/10.1021/acsomega.9b01476
Ryumin, P. and Cramer, R. (2018) The composition of liquid atmospheric pressure matrix-assisted laser desorption/ionization matrices and its effect on ionization in mass spectrometry. Analytica Chimica Acta , 1013 pp. 43-53. ISSN: 1873-4324 | doi: https://dx.doi.org/10.1016/j.aca.2018.01.070
Hale, O. and Cramer, R. (2018) Collision-induced dissociation of doubly-charged barium-cationized lipids generated from liquid samples by atmospheric pressure matrix-assisted laser desorption/ionization provides structurally diagnostic product ions. Analytical and Bioanalytical Chemistry , 410 (5). pp. 1435-1444. ISSN: 1618-2650 | doi: https://dx.doi.org/10.1007/s00216-017-0788-6
Brown, J. , Morris, M. , Cramer, R. (2017) Liquid AP-MALDI: ion signal intensity and persistence at laser repetition rates between 1 Hz and 5 kHz.
Wiangnon, K. and Cramer, R. (2016) Liquid MALDI MS analysis of complex peptide and proteome samples. Journal of Proteome Research , 15 (9). pp. 2998-3008. ISSN: 1535-3907 | doi: https://dx.doi.org/10.1021/acs.jproteome.6b00148
Wiangnon, K. and Cramer, R. (2016) Coupling liquid MALDI MS to liquid chromatography. In: Cramer, R. , (eds.) Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry. Springer pp. 65-76. ISBN: 9783319048185 | doi: https://dx.doi.org/10.1007/978-3-319-04819-2_4
Ryumin, P. , Brown, J. , Morris, M. , Cramer, R. (2016) Investigation and optimization of parameters affecting the multiply charged ion yield in AP-MALDI MS. Methods , 104 pp. 11-20. ISSN: 1046-2023 | doi: https://dx.doi.org/10.1016/j.ymeth.2016.01.015
Ryumin, P. and Cramer, R. (2016) Efficient production of multiply charged MALDI ions. In: Cramer, R. , (eds.) Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry. Springer pp. 37-47. ISBN: 9783319048185 | doi: https://dx.doi.org/10.1007/978-3-319-04819-2_2
Cramer, R. , Pirkl, A. , Hillenkamp, F. , Dreisewerd, K. (2013) Liquid AP-UV-MALDI enables stable ion yields of multiply charged peptide and protein ions for sensitive analysis by mass spectrometry. Angewandte Chemie-International Edition , 52 (8). pp. 2364-2367. ISSN: 1521-3773 | doi: https://dx.doi.org/10.1002/anie.201208628
On High-throughput Screening LAP-MALDI-MS
Krenkel, H. , Brown, J. , Richardson, K. , Hoyes, E. , Morris, M. , Cramer, R. (2022) Ultrahigh-throughput sample analysis using liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Analytical Chemistry , 94 (10). pp. 4141-4145. ISSN: 0003-2700 | doi: https://dx.doi.org/10.1021/acs.analchem.1c05614
Piras, C. , Hale, O. , Reynolds, C. , Jones, A. , Taylor, N. , Morris, M. , Cramer, R. (2022) LAP-MALDI MS coupled with machine learning: an ambient mass spectrometry approach for high-throughput diagnostics. Chemical Science , 13 (6). pp. 1746-1758. ISSN: 1478-6524 | doi: https://dx.doi.org/10.1039/D1SC05171G
Piras, C. , Hale, O. , Reynolds, C. , Jones, A. , Taylor, N. , Morris, M. , Cramer, R. (2021) Speciation and milk adulteration analysis by rapid ambient liquid MALDI mass spectrometry profiling using machine learning. Scientific Reports , 11 (1). ISSN: 2045-2322 | doi: https://dx.doi.org/10.1038/s41598-021-82846-5
Piras, C. , Ceniti, C. , Hartmane, E. , Costanzo, N. , Morittu, V. , Roncada, P. , Britti, D. , Cramer, R. (2020) Rapid liquid AP-MALDI MS profiling of lipids and proteins from goat and sheep milk for speciation and colostrum analysis. Proteomes , 8 (3). ISSN: 2227-7382 | doi: https://dx.doi.org/10.3390/proteomes8030020
Cramer, R. (2020) High-speed analysis of large sample sets – how can this key aspect of the omics be achieved?. Molecular and Cellular Proteomics , 19 (11). pp. 1760-1766. ISSN: 1535-9484 | doi: https://dx.doi.org/10.1074/mcp.P120.001997
Krenkel, H. , Hartmane, E. , Piras, C. , Brown, J. , Morris, M. , Cramer, R. (2020) Advancing liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry toward ultra-high-throughput analysis. Analytical Chemistry , 92 (4). pp. 2931-2936. ISSN: 0003-2700 | doi: https://dx.doi.org/10.1021/acs.analchem.9b05202
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