Cardiovascular diseases and type 2 diabetes are the greatest cause of morbidity and mortality globally, with diet considered as a key modulator of risk. We are internationally recognised for our research examining the role of diet and nutrition on cardiometabolic health and disease risk, with particular expertise in lipoprotein metabolism, insulin resistance, inflammation and vascular function. We combine expertise in randomised human intervention studies together with state of the art non-invasive techniques to examine the physiological effects of dietary change on cardiometabolic risk markers, in combination with a range of cell culture approaches to investigate molecular mechanisms. Complex analysis of large population cohorts also provides insight into the role of genes on responsiveness to dietary modulation and disease risk.