INFORM are delighted to announce the funding award for a Feasibility Study Project ”Impact of a novel functional snack on perimenopausal symptoms and well-being: a pilot study”, led by Professor Ana Rodriguez-Mateos.
Project Team:
Professor Ana Rodriguez-Mateos – Kings College London (PI)
Monica Martini – The Tula Code
The project addresses the significant physical and psychological symptoms experienced by women during perimenopause, including mood disturbances, anxiety, poor sleep, vasomotor symptoms, gastrointestinal discomfort, and reduced well-being. These symptoms are linked to hormonal changes—particularly declining oestrogen—which also disrupt the gut microbiome, increasing inflammation and contributing to cardiometabolic and mental health risks. There is a clear need for effective, non-pharmacological strategies to support women during this life transition.
Project Aims:
The Study aims to:
- Investigate whether daily consumption of a novel functional snack rich in dietary fibre and phytochemicals can improve perimenopausal symptoms and overall well-being.
- Explore gut microbiota–mediated mechanisms, including changes in microbial diversity, gut-derived metabolites, stress hormones, and female sex hormones.
- Assess effects on mood, anxiety, depression, sleep quality, vasomotor symptoms, and gastrointestinal symptoms using validated questionnaires.
- Establish feasibility, acceptability, and preliminary efficacy through a double-blind, randomised crossover pilot study in perimenopausal women.
Potential Impact:
The project offers significant scientific, clinical, and commercial value by providing early evidence for a diet-based, non-pharmacological approach to managing perimenopausal symptoms. It advances the understanding of the gut–hormone–brain axis, informs larger future trials, supports the development of menopause-targeted functional foods, and promotes accessible strategies to improve quality of life for perimenopausal women.
