{"id":1462,"date":"2025-12-09T23:59:01","date_gmt":"2025-12-09T23:59:01","guid":{"rendered":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/?p=1462"},"modified":"2025-12-10T17:22:07","modified_gmt":"2025-12-10T17:22:07","slug":"fma-impact-jarrett","status":"publish","type":"post","link":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/fma-impact-jarrett\/","title":{"rendered":"Funding Award – FMA Impact Report: Heights"},"content":{"rendered":"

INFORM are delighted to announce the funding award for an FMA Impact Report<\/strong>\u00a0 “The role of the Gut Microbiome in Cognition & Dementia risk<\/strong>“, led by Dr Harry Jarrett, Head of Science & Research, Heights.<\/p>\n

Project Team:<\/strong><\/p>\n

Dr Harry Jarrett – Heights (PI)
\nDr Catherine Hughes – NICHE, Ulster University
\nDr Ryan McNally – Kings College London
\nMs Sophie Medlin – City Dieticians
\nMs Lisa Holton – Heights<\/p>\n

This project focuses on Dementia, a progressive cognitive disorder affecting nearly 982,000 people in the UK. With one in three individuals expected to develop Dementia and 45% of cases considered potentially preventable, the proposal highlights the urgent need for strategies that target modifiable risk factors.<\/p>\n

A key area of interest is the age-related decline in gut microbiome diversity, which has been linked to poorer cognitive outcomes and increased Dementia risk. The project also addresses the heightened vulnerability of women due to menopause-related hormonal changes that further reduce microbiome diversity.<\/p>\n

\n

The project aims to:<\/strong><\/p>\n

    \n
  1. \n

    Conduct a comprehensive systematic review and meta-analysis<\/strong> of randomised controlled trials assessing the impact of gut-modulating products (probiotics, prebiotics, synbiotics) on cognitive function.<\/p>\n<\/li>\n

  2. \n

    Examine subgroup differences<\/strong>, including age, sex, ethnicity, health status, and disease state.<\/p>\n<\/li>\n

  3. \n

    Investigate the relationship between the gut microbiome, oestrogen concentrations, and cognition<\/strong>, with a specific focus on female Dementia risk.<\/p>\n<\/li>\n

  4. \n

    Develop an accessible impact document<\/strong> summarising current evidence for healthcare providers and policymakers.<\/p>\n<\/li>\n

  5. \n

    Produce two peer-reviewed publications<\/strong> to advance academic knowledge.<\/p>\n<\/li>\n

  6. \n

    Estimate economic savings<\/strong> using health-economic modelling to evaluate how gut-modulating interventions could reduce the national Dementia burden.<\/p>\n<\/li>\n<\/ol>\n

    \n

    Potential Impact:<\/strong><\/p>\n

    The project has the potential to advance understanding of how gut-modulating products support cognitive health and reduce Dementia risk, with particular relevance for women\u2019s brain health during and after menopause.<\/p>\n

    Its accessible impact report will help inform policy and clinical practice, while fostering stronger collaboration between academic, clinical, and industry partners.<\/p>\n

    By modelling potential cost savings to the UK health and social care system, the project also provides important economic insights. Additionally, the findings will assist the development of future gut-brain health interventions aimed at improving wellbeing across the population.<\/p>\n

    The project will run from June through to the end of 2025.<\/p>\n\n\n\n
    \"\"<\/a><\/td>\n\"\"<\/a><\/td>\n\"\"<\/a><\/td>\n\"\"<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \n","protected":false},"excerpt":{"rendered":"

    INFORM are delighted to announce the funding award for an FMA Impact Report\u00a0 “The role of the Gut Microbiome in Cognition & Dementia risk“, led by Dr Harry Jarrett, Head…Read More ><\/a><\/p>\n","protected":false},"author":711,"featured_media":1463,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"__cvm_playback_settings":[],"__cvm_video_id":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[8],"tags":[],"coauthors":[13],"class_list":["post-1462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"featured_image_src":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-content\/uploads\/sites\/297\/2025\/12\/FMA-Impact-Report-Funding-Announcement.jpg","author_info":{"display_name":"Fiona Lee","author_link":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/author\/jk903657reading-ac-uk\/"},"cc_featured_image_caption":{"caption_text":"","source_text":"","source_url":""},"_links":{"self":[{"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/posts\/1462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/users\/711"}],"replies":[{"embeddable":true,"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/comments?post=1462"}],"version-history":[{"count":10,"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/posts\/1462\/revisions"}],"predecessor-version":[{"id":1512,"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/posts\/1462\/revisions\/1512"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/media\/1463"}],"wp:attachment":[{"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/media?parent=1462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/categories?post=1462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/tags?post=1462"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/research.reading.ac.uk\/inform-innovation-hub\/wp-json\/wp\/v2\/coauthors?post=1462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}