{"id":183,"date":"2019-04-30T12:48:32","date_gmt":"2019-04-30T11:48:32","guid":{"rendered":"https:\/\/research.reading.ac.uk\/swsbc2019\/?page_id=183"},"modified":"2020-07-24T11:56:07","modified_gmt":"2020-07-24T10:56:07","slug":"programme","status":"publish","type":"page","link":"https:\/\/research.reading.ac.uk\/swsbc2020\/programme\/","title":{"rendered":"SWSBC2020 Programme – FINAL"},"content":{"rendered":"

FEEDBACK FORM – please click here <\/a>to complete the feedback for this meeting. We value your input!<\/h1>\n

 <\/p>\n

<\/h1>\n

ABSTRACT BOOK CAN BE DOWNLOADED FROM SWSBC-PROGRAMME-GRAPHICAL-ABSTRACTS<\/a>.<\/h2>\n

 <\/p>\n

SWSBC2020 oral sessions<\/h2>\n

 <\/p>\n

 <\/p>\n

Day 1: <\/u><\/strong>Monday 20.07.20<\/u><\/h2>\n

 <\/p>\n

Session 1 –<\/strong>\u00a0CryoEM of molecular machines and assemblies <\/strong><\/h2>\n

Hosted by Exeter (Vicki Gold, Bertram Daum and Simone de Rose)<\/p>\n

Click here <\/a>to link to the recorded session.<\/h2>\n

08:45-09:00\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Welcome<\/p>\n

 <\/p>\n

09:00-09:10\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Patricia Gil Diez* – Structure of a eukaryotic hibernating ribosome dimer from the fungal parasite\u00a0Spraguea lophii<\/em>.<\/p>\n

09:15-09:25\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alexander Neuhaus\u00a0–\u00a0Cryo-electron microscopy reveals two distinct type IV pili assembled by the same bacterium<\/p>\n

09:30-09:40\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Lavinia Gambelli\u00a0–\u00a0Architecture and modular assembly of Sulfolobus<\/em> acidocaldarius<\/em> S-layer revealed by electron cryomicroscopy<\/p>\n

09:45-09:55\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kapil Gupta*\u00a0–\u00a0Unexpected free fatty acid binding pocket in SARS-CoV-2 spike: path to new antivirals?<\/p>\n

10:00-10:10\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ka\u00efn van den Elsen\u00a0–\u00a0The Structural Basis of the Flavivirus Replication Process<\/p>\n

10:15-10:25\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Nik Harmer – A Micro-ED facility for SWSBC<\/p>\n

10:30-10:45\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ufuk Borucu –\u00a0The\u00a0GW4 Regional Facility for High-Resolution cryoEM<\/p>\n

 <\/p>\n

 <\/p>\n

Session 2 \u2013<\/strong>\u00a0Enzymes 1 <\/strong><\/h2>\n

Hosted by Bristol (Jim Spencer and Leo Brady)<\/p>\n

Click here<\/a> to link to the recorded session.<\/h2>\n

11:00-11:20\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Greg Pollard \u2013 Lysyl oxidase: self-healing with biocatalysts<\/p>\n

11:30-11:40\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Rachel Bolton\u00a0–\u00a0Data Collection Strategies for the Radiation Sensitive, Ferric Iron Binding Protein, FutA<\/p>\n

11:45-11:55\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Charlie Collingham – The Link between Mitochondrial Dysfunction, Bile Acids and Neurodegenerative Disease<\/p>\n

12:00-12:10\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Simone Antonio De Rose* – HotSolute: Thermus thermophilus as a Whole Cell Factory for the Production of Extremolytes<\/p>\n

12:15-12:25\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Geoffrey Masuyer – Crystal Structure of Exotoxin A from Aeromonas<\/em> Pathogenic Species<\/p>\n

12:30-12:45\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 General Q&A<\/p>\n

 <\/p>\n

 <\/p>\n

CCP4 ROADSHOW <\/strong><\/h2>\n

13:00-13:30\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Setting up CCP4 on your computer<\/p>\n

\u00a0<\/strong><\/p>\n

PLENARY<\/strong><\/h2>\n

14:00-15:00\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alan Cheung – Structure and function of chromatin modifying complexes SAGA and NuA4<\/p>\n

Click here<\/a> to link to the recorded session.<\/h2>\n

 <\/p>\n

Session 3 \u2013<\/strong>\u00a0Protein interactions and disease<\/strong><\/h2>\n

Hosted by Cardiff (Dafydd Jones)<\/p>\n

Click here<\/a> to link to the recorded session.<\/h2>\n

15:15-15:25\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hayden Fisher \u2013 Hinge region disulfide patterns dictate activity in human IgG2 antibodies through conformational restriction<\/p>\n

15:30-15:40\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Rhys Dunphy*\u00a0–\u00a0Elucidating the N-terminal strand swapping mechanism exhibited by C3d dimers in the presence of a Staphylococcus aureus<\/em> immune evasion protein<\/p>\n

15:45-15:55\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Rory Munroe* – What is the role of S100A9 in the onset of neurodegenerative disease?<\/p>\n

16:00-16:10\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alessandro Agnarelli* – Analysing IRF4 interactions to ISRE motifs in Multiple Myeloma<\/p>\n

16:15-16:40\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Daren Fearon \u2013 Crystallographic fragment screening of the SARS-CoV-2 main protease and crowdsourcing the development of antiviral drugs<\/p>\n

 <\/p>\n

 <\/p>\n

POSTER SESSION<\/strong><\/h2>\n

Hosted by Southampton (Phil Williamson and Ivo Tews)<\/p>\n

 <\/p>\n

18:00-18:05\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Brief introduction to online posters<\/p>\n

18:00-20:00\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Visit the poster inn MS teams, just select the channel with the poster you are interested in, watch the clip, and ask the presenter questions<\/p>\n

18:30-19:30\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Poster pitches, 2.5 mins each<\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

SOCIAL<\/strong><\/h2>\n

Hosted by Reading (Charlie Collingham & many others, Kim Watson)<\/p>\n

20:00-???\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Main event and breakout rooms<\/p>\n

 <\/p>\n

 <\/p>\n

Day 2: <\/u><\/strong>Tuesday 21.07.20<\/u><\/h2>\n

 <\/p>\n

CCP4 ROADSHOW <\/strong><\/h2>\n

09:00-11:45\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 MR, Phasing, Refinement (Ed Lowe & Stuart McNicholas)<\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

CCPN ROADSHOW <\/strong><\/h2>\n

09:30-11:30\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Introduction, Assignments and Titrations (Vicky Higman)<\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

PLENARY<\/strong><\/h2>\n

12:00-13:00\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Allen Orville \u2013 Time-resolved serial femtosecond crystallography of the early intermediates in the isopenicillin N synthase reaction with ACV and O2<\/p>\n

\u00a0Click here<\/a> to link to the recorded session.
\n<\/strong><\/h2>\n

\u00a0<\/strong><\/p>\n

Session 4 \u2013<\/strong>\u00a0Biotechnology<\/strong><\/h2>\n

Hosted by Portsmouth (John Mc Geehan)<\/p>\n

Click here<\/a> to link to the recorded session.<\/h2>\n

13:15-13:25\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Erik Landin – The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor (1)<\/p>\n

13:30-13:40\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alexander J Lander – Total Chemical Synthesis and Racemic Protein Crystallography of Bacteriocins (2)<\/p>\n

13:45-13:55\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Sam Robson – Sequencing and Tracking of Phylogeny in COVID-19: A Genomic Epidemiological Approach to the COVID-19 Pandemic (3)<\/p>\n

14:00-14:10\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Maria Concistr\u00e8 – 1Strategies for 1H-detected dynamic nuclear polarization magic-angle spinning NMR (4)<\/p>\n

14:15-14:25\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Emiliana De Santis* – Peptide virus-like particles: from synthetic biologics to reference standards for advanced therapies (5)<\/p>\n

14:30-15:00\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 General Q&A<\/p>\n

 <\/p>\n

 <\/p>\n

Session 5 \u2013<\/strong>\u00a0Enzymes 2<\/strong><\/h2>\n

Hosted by Bath (Susan Crennell)<\/p>\n

Click here<\/a> to link to the recorded session.<\/h2>\n

15:15-15:25\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Charlotte Colenso – Simulation strategies for zinc metalloenzymes applied to metallo-\u03b2-lactamases<\/p>\n

15:30-15:40\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Daniel Mitchell* – A novel sensor for measuring femto-Newton forces in enzyme turnover and the importance of good crystallographic data<\/p>\n

15:45-15:55\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Paul James – A Novel \u2018Split-gene\u2019 transketolase from the hyper-thermophilic bacterium Carboxydothermus hydrogenoformans<\/em>: structure and biochemical characterisation<\/p>\n

16:00-16:10\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00c9il\u00eds Bragginton – Insight into the structure and function of OXA-57; a class-D \u03b2-lactamase from Burkholderia pseudomallei<\/em><\/p>\n

 <\/p>\n

16:15-17:00\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 PRIZES & CLOSING (Kim Watson, John McGeehan)<\/strong><\/p>\n

 <\/p>\n

* Also presents a poster<\/p>\n","protected":false},"excerpt":{"rendered":"

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