Sarah Needs

 

2022

• Needs, S. , Saiprom, N. , Rafaque, Z. , Imtiaz, W. , Chantratita, N. , Runcharoen, C. , Thammachote, J. , Anun, S. , Peacock, S. , Ray, P.  , Andrews, S. , Edwards, A.  (2022) Miniaturised broth microdilution for simplified antibiotic susceptibility testing of Gram negative clinical isolates using microcapillary devices. Analyst ISSN: 0003-2654
• Needs, S.  , Sirivisoot, S.  , Jegouic, S. , Prommool, T. , Luangaram, P. , Srisawat, C. , Sriraksa, K. , Limpitikul, W. , Mairiang, D.  , Malasit, P. , Avirutnan, P.  , Puttikhunt, C. , Edwards, A.  (2022) Smartphone multiplex microcapillary diagnostics using Cygnus: development and evaluation of rapid serotype-specific NS1 detection with dengue patient samples. PLOS Neglected Tropical Diseases , 16 (4). pp 0. ISSN: 1935-2735 | doi: https://dx.doi.org/10.1371/journal.pntd.0010266

2021

• Needs, S. , Bootman, M. , Grotzke, J. , Kramer, H. , Allman, S. (2021) Off-target inhibition of NGLY1 by the poly-caspase inhibitor Z-VAD-fmk induces cellular autophagy. The FEBS Journal ISSN: 1742-464X | doi: https://dx.doi.org/10.1111/febs.16345
• Needs, S. , Donmez, S. , Edwards, A.  (2021) Direct microfluidic antibiotic resistance testing in urine with smartphone capture: significant variation in sample matrix interference between individual human urine samples. RSC Advances , 11 (60). pp. 38258-38263. ISSN: 2046-2069 | doi: https://dx.doi.org/10.1039/D1RA06867A
• Needs, S., Osborn, H. and Edwards, A.  (2021) Counting bacteria in microfluidic devices: smartphone compatible ‘dip-and-test’ viable cell quantitation using resazurin amplified detection in microliter capillary arrays. Journal of Microbiological Methods. ISSN 0167-7012 (In Press)

 

2020

• Sarah H. Needs, Sultan I. Donmez, Stephanie P. Bull, Conor McQuaid, Helen M. Osborn and Alexander D. Edwards. (2020) Challenges in microfluidic and point-of-care phenotypic antimicrobial resistance tests. Front. Mech. Eng. | doi: 10.3389/fmech.2020.00073
• Sultan İlayda Dönmez, Sarah H. Needs, Helen M.I. Osborn, Alexander D. Edwards. (2020) Label-free smartphone quantitation of bacteria by darkfield imaging of light scattering in fluoropolymer micro capillary film allows portable detection of bacteriophage lysis ,Sensors and Actuators B: Chemical, Volume 323,128645, ISSN 0925-4005, https://doi.org/10.1016/j.snb.2020.128645.
• Bull, S. Needs, S and Edwards, A. (2020) Building open lab hardware to tackle antimicrobial resistance. Open Research Case Studies. Report. University of Reading doi: https://doi.org/10.17864/1926.89600
• Needs SH, Bull SP, Bravo J et al. Remote videolink observation of model home sampling and home testing devices to simplify usability studies for point-of-care diagnostics [version 1; peer review: awaiting peer review]. Wellcome Open Res 2020, 5:174 (https://doi.org/10.12688/wellcomeopenres.16105.1)
• Vesty, E.F., Whitbread, A.L., Needs, S. et al. Cross-kingdom signalling regulates spore germination in the moss Physcomitrella patens. Sci Rep 10, 2614 (2020). https://doi.org/10.1038/s41598-020-59467-5

2019

• Needs SH, Diep TT, Bull SP, Lindley-Decaire A, Ray P, Edwards AD (2019) Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology. PLoS ONE 14(11): e0224878. https://doi.org/10.1371/journal.pone.0224878
• Robert J. Evans, Katherine Pline, Catherine A. Loynes, Sarah Needs, Maceler Aldrovandi, Jens Tiefenbach, Ewa Bielska, Rachel E. Rubino, Christopher J. Nicol, Robin C. May, Henry M. Krause, Valerie B. O’Donnell, Stephen A. Renshaw, Simon A. Johnston. 15-keto-prostaglandin E₂ activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLOS Pathogens Published: March 28, 2019. https://doi.org/10.1371/journal.ppat.1007597

2016

• Eleanor F. Vesty,  Younousse Saidi,  Laura A. Moody,  Daniel Holloway,  Amy Whitbread,  Sarah Needs, Anushree Choudhary,  Bethany Burns,  Daniel McLeod, Susan J. Bradshaw, Hansol Bae, Brian Christopher King, George W. Bassel, Henrik Toft Simonsen, Juliet C. Coates. The decision to germinate is regulated by divergent molecular networks in spores and seeds. The New Phytologist. Published online 2016 Jun 3. doi: 10.1111/nph.14018