SWSBC2020 Programme – FINAL
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ABSTRACT BOOK CAN BE DOWNLOADED FROM SWSBC-PROGRAMME-GRAPHICAL-ABSTRACTS.
SWSBC2020 oral sessions
Day 1: Monday 20.07.20
Session 1 – CryoEM of molecular machines and assemblies
Hosted by Exeter (Vicki Gold, Bertram Daum and Simone de Rose)
Click here to link to the recorded session.
08:45-09:00 Welcome
09:00-09:10 Patricia Gil Diez* – Structure of a eukaryotic hibernating ribosome dimer from the fungal parasite Spraguea lophii.
09:15-09:25 Alexander Neuhaus – Cryo-electron microscopy reveals two distinct type IV pili assembled by the same bacterium
09:30-09:40 Lavinia Gambelli – Architecture and modular assembly of Sulfolobus acidocaldarius S-layer revealed by electron cryomicroscopy
09:45-09:55 Kapil Gupta* – Unexpected free fatty acid binding pocket in SARS-CoV-2 spike: path to new antivirals?
10:00-10:10 Kaïn van den Elsen – The Structural Basis of the Flavivirus Replication Process
10:15-10:25 Nik Harmer – A Micro-ED facility for SWSBC
10:30-10:45 Ufuk Borucu – The GW4 Regional Facility for High-Resolution cryoEM
Session 2 – Enzymes 1
Hosted by Bristol (Jim Spencer and Leo Brady)
Click here to link to the recorded session.
11:00-11:20 Greg Pollard – Lysyl oxidase: self-healing with biocatalysts
11:30-11:40 Rachel Bolton – Data Collection Strategies for the Radiation Sensitive, Ferric Iron Binding Protein, FutA
11:45-11:55 Charlie Collingham – The Link between Mitochondrial Dysfunction, Bile Acids and Neurodegenerative Disease
12:00-12:10 Simone Antonio De Rose* – HotSolute: Thermus thermophilus as a Whole Cell Factory for the Production of Extremolytes
12:15-12:25 Geoffrey Masuyer – Crystal Structure of Exotoxin A from Aeromonas Pathogenic Species
12:30-12:45 General Q&A
CCP4 ROADSHOW
13:00-13:30 Setting up CCP4 on your computer
PLENARY
14:00-15:00 Alan Cheung – Structure and function of chromatin modifying complexes SAGA and NuA4
Click here to link to the recorded session.
Session 3 – Protein interactions and disease
Hosted by Cardiff (Dafydd Jones)
Click here to link to the recorded session.
15:15-15:25 Hayden Fisher – Hinge region disulfide patterns dictate activity in human IgG2 antibodies through conformational restriction
15:30-15:40 Rhys Dunphy* – Elucidating the N-terminal strand swapping mechanism exhibited by C3d dimers in the presence of a Staphylococcus aureus immune evasion protein
15:45-15:55 Rory Munroe* – What is the role of S100A9 in the onset of neurodegenerative disease?
16:00-16:10 Alessandro Agnarelli* – Analysing IRF4 interactions to ISRE motifs in Multiple Myeloma
16:15-16:40 Daren Fearon – Crystallographic fragment screening of the SARS-CoV-2 main protease and crowdsourcing the development of antiviral drugs
POSTER SESSION
Hosted by Southampton (Phil Williamson and Ivo Tews)
18:00-18:05 Brief introduction to online posters
18:00-20:00 Visit the poster inn MS teams, just select the channel with the poster you are interested in, watch the clip, and ask the presenter questions
18:30-19:30 Poster pitches, 2.5 mins each
SOCIAL
Hosted by Reading (Charlie Collingham & many others, Kim Watson)
20:00-??? Main event and breakout rooms
Day 2: Tuesday 21.07.20
CCP4 ROADSHOW
09:00-11:45 MR, Phasing, Refinement (Ed Lowe & Stuart McNicholas)
CCPN ROADSHOW
09:30-11:30 Introduction, Assignments and Titrations (Vicky Higman)
PLENARY
12:00-13:00 Allen Orville – Time-resolved serial femtosecond crystallography of the early intermediates in the isopenicillin N synthase reaction with ACV and O2
Click here to link to the recorded session.
Session 4 – Biotechnology
Hosted by Portsmouth (John Mc Geehan)
Click here to link to the recorded session.
13:15-13:25 Erik Landin – The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor (1)
13:30-13:40 Alexander J Lander – Total Chemical Synthesis and Racemic Protein Crystallography of Bacteriocins (2)
13:45-13:55 Sam Robson – Sequencing and Tracking of Phylogeny in COVID-19: A Genomic Epidemiological Approach to the COVID-19 Pandemic (3)
14:00-14:10 Maria Concistrè – 1Strategies for 1H-detected dynamic nuclear polarization magic-angle spinning NMR (4)
14:15-14:25 Emiliana De Santis* – Peptide virus-like particles: from synthetic biologics to reference standards for advanced therapies (5)
14:30-15:00 General Q&A
Session 5 – Enzymes 2
Hosted by Bath (Susan Crennell)
Click here to link to the recorded session.
15:15-15:25 Charlotte Colenso – Simulation strategies for zinc metalloenzymes applied to metallo-β-lactamases
15:30-15:40 Daniel Mitchell* – A novel sensor for measuring femto-Newton forces in enzyme turnover and the importance of good crystallographic data
15:45-15:55 Paul James – A Novel ‘Split-gene’ transketolase from the hyper-thermophilic bacterium Carboxydothermus hydrogenoformans: structure and biochemical characterisation
16:00-16:10 Éilís Bragginton – Insight into the structure and function of OXA-57; a class-D β-lactamase from Burkholderia pseudomallei
16:15-17:00 PRIZES & CLOSING (Kim Watson, John McGeehan)
* Also presents a poster