We are interested in investigating the effects of an enzyme-treated asparagus stem (ETAS®) supplement on brain function and thinking abilities. Asparagus contains natural compounds, including antioxidants, which may help protect the brain and support healthy ageing. Enzyme treated asparagus stem (ETAS®) supplements, has been linked in previous research to improvements in mood, sleep and certain aspects of cognitive function. In this study, we will explore how ETAS® affects cognition and brain activity in adults aged 60–80 years. This research will help us better understand whether ETAS® could be a useful nutritional supplement for supporting brain health as we age.
To participate, you must:
- Be aged 60–80 years
- Have normal or corrected-to-normal vision and hearing
- Have a body mass index (BMI) between 18.5 and 30
Unfortunately, you would not be able to take part if any of the following apply:
- General health and lifestyle: You smoke You have any food allergies You follow a restrictive or unbalanced diet (e.g. vegetarian, vegan, or weight-loss diets) You have recently changed your diet within the past month
- Medical conditions: You have been diagnosed with a psychiatric or neurological condition (e.g. depression, schizophrenia, dementia, or eating disorders) You have cardiometabolic conditions (e.g. type II diabetes, cardiovascular disease), high blood pressure, clotting disorders, or thyroid disease You have a significant gastrointestinal condition affecting digestion or absorption (e.g. inflammatory bowel disease, major bowel surgery, end-stage renal disease, or cancer within the past 3 years) You have a history of epilepsy
- Medications and supplements: You are currently taking anticoagulants, antiplatelet medication, antidepressants, or proton-pump inhibitors You are currently taking prebiotic or probiotic supplements – you may be asked to stop taking to participate You have taken antibiotics continuously for more than 3 days in the past month You have been using weight-loss medication for more than 1 month
- MRI Safety Scanning: You have claustrophobia You have a pacemaker, artificial heart valve, or any implanted medical device (e.g. cochlear implant, nerve stimulator, infusion pump) You have metal in your body (e.g. from surgery, injury, or implants), excluding standard dental fillings You have had surgery involving metal implants You have metal fragments in your body (e.g. from injury) You wear hearing aids You have body piercings you cannot remove You wear transdermal patches containing metal You have an intrauterine device (IUD) You have tattoos or permanent makeup that may affect scanning
To get involved, please contact Abigail Davies at abigail.davies@pgr.reading.ac.uk