My lab focuses on the drivers and consequences of intra-individual variation in platelet function. Within this broader remit, we currently have a number of specific focuses. 1) To develop platelet function tests that either more accurately reflect the action of platelets in thrombosis or that are suitable for rapid analysis of platelet function in primary care and for large scale genetic or epidemiological research. 2) To investigate the molecular mechanisms that drive intra-individual variation and maybe potential drug targets. We’re currently investigating the role of ILK in integrin αIIbβ3 clustering and Carbonic Anhydrases in thrombus formation. 3) To identify the factors that alter platelet function and their effect. We’re currently investigating the effect of age, n-3 polyunsaturated fatty acids and insulin resistance.
